Work

Bifunctional coumarin derivatives that inhibit transthyretin amyloidogenesis and serve as fluorescent transthyretin folding sensors

Year: 2013

Type: article

Abstract: We describe coumarin derivatives that are non-fluorescent in aqueous buffers and that very selectively bind to transthyretin (TTR) in complex biological environments potently inhibiting TTR amyloidogenesis while also exhibiting sensitive off-on fluorescent sensing of the properly folded quaternary structure of TTR.

Source: Chemical Communications

DOI: 10.1039/c3cc44667k

Authors: Nojoon Myung, Stephen Connelly, Boyoung Kim, Sung Jean Park, Ian A. Wilson, Jeffery W. Kelly, Sungwook Choi

Institutions: Chungnam National University, Scripps Research Institute, Gachon University

Language: English

Topic: Amyloidosis: Diagnosis, Treatment, Outcomes

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Research Resources

Awards: G113944070, G1800297237, G2269286100, G2300450775, G466926004, G6579817608, A Synchrotron Radiation Structural Biology Resource

OpenAlex ID: W1986709407

FWCI: 1.075

Cites: 39

Cited by: 43

Related to: 10