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853. Monitoring of Promoter-Controlled Adenoviral Replication with Noninvasive Imaging in Lung Cancer

Year: 2006

Type: article

Abstract: The employment of conditionally replicative adenoviruses (CRAds) provides a novel way to treat lung cancer. To maintain safety and efficacy in clinical application, a noninvasive detection system of viral replication is required. However, there are currently no available methods to dynamically monitor adenovirus replication and spreading ability in clinical settings. Recently we have shown that the EGFP reporter gene placed in the deleted E3 region under the adenoviral major late promoter could be exploited to noninvasively monitor adenovirus replication.

Source: Molecular Therapy

DOI: 10.1016/j.ymthe.2006.08.939

Authors: Julia Davydova, Amy R. Nelson, Tatyana Gavrikova, Long P. Le, Hidetaka A. Ono, David T. Curiel, Masato Yamamoto

Language: English

Topic: Virus-based gene therapy research

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,500

OpenAlex ID: W1986741691

FWCI:

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