Work

In Vivo Gene Delivery by Nonviral Vectors: Overcoming Hurdles?

Year: 2012

Type: review

Abstract: The promise of cancer gene therapeutics is hampered by difficulties in the in vivo delivery to the targeted tumor cells, and systemic delivery remains to be the biggest challenge to be overcome. Here, we concentrate on systemic in vivo gene delivery for cancer therapy using nonviral vectors. In this review, we summarize the existing delivery barriers together with the requirements and strategies to overcome these problems. We will also introduce the current progress in the design of nonviral vectors, and briefly discuss their safety issues.

Source: Molecular Therapy

DOI: 10.1038/mt.2012.79

Authors: Yuan Zhang, Andrew Satterlee, Leaf Huang

Institution: University of North Carolina at Chapel Hill

Language: English

Topic: RNA Interference and Gene Delivery

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,500