Work

Epithelial to mesenchymal transition and breast cancer

Year: 2009

Type: review

Abstract: Epithelial-mesenchymal plasticity in breast carcinoma encompasses the phenotypic spectrum whereby epithelial carcinoma cells within a primary tumor acquire mesenchymal features and re-epithelialize to form a cohesive secondary mass at a metastatic site. Such plasticity has implications in progression of breast carcinoma to metastasis, and will likely influence response to therapy. The transcriptional and epigenetic regulation of molecular and cellular processes that underlie breast cancer and result in characteristic changes in cell behavior can be monitored using an increasing array of marker proteins. Amongst these markers exists the potential for emergent prognostic, predictive and therapeutic targeting.

Source: Breast Cancer Research

DOI: 10.1186/bcr2416

Authors: Eva Tomaskovic-Crook, Erik W Thompson, Jean Paul Thiery

Institutions: Institute of Molecular and Cell Biology, The University of Melbourne, St Vincent's Hospital Melbourne

Language: English

Topic: Cancer Cells and Metastasis

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,190