Work

Genetics and molecular biology: phospholipid transfer protein in atherogenesis

Year: 2006

Type: review

Abstract: Human phospholipid transfer protein (PLTP) is a 476 amino acid secreted protein that catalyzes the transfer of phospholipids and vitamin E between lipoprotein particles. PLTP plays a key role in the formation and homeostasis of high-density lipoprotein (HDL) particles; it transfers phospholipids from very-low-density lipoprotein (VLDL) surface remnants to HDL particles, it facilitates the interconversion of HDL subclasses, and generates lipid-poor pre?-HDL particles. PLTP is synthesized by various cell types but its primary function is in the plasma where it is transported in association with apolipoproteins. Plasma PLTP exists in two forms: a high activity form that co-purifies with apolipoprotein (apo) E and a low activity form associated with apoA-I. It was reported recently that both apoE and apoA-IV can activate PLTP.

Source: Current Opinion in Lipidology

DOI: 10.1097/mol.0b013e328010a016

Authors: David Akopian, Jheem D Medh

Institution: California State University, Northridge

Language: English

Topic: Cholesterol and Lipid Metabolism

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of General Medical Sciences