Work

Lentiviral encephalitides in the immature host: A comparison of human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV) brain infection

Year: 1989

Type: review

Abstract: The human immunodeficiency virus (HIV) and the simian immunodeficiency virus (SIV) are members of the lentivirus subfamily of retroviruses. Both are capable of establishing persistent infection in the nervous system and both demonstrate increased virulence in the immature of their respective host species. Brain infection with these primate lentiviruses share common virologic and neuropathologic features. The available evidence to date suggests that viral factors may determine neuroinvasiveness and possibly neurovirulence, but that host factors may be largely responsible for the neuropathologic changes observed.

Source: Brain and Development

DOI: 10.1016/s0387-7604(89)80016-6

Author: Leon G Epstein

Institutions: University of Rochester Medicine, University of Rochester

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $2,810