Work

Effector memory regulatory T-cell expansion marks a pivotal point of immune escape in myelodysplastic syndromes

Year: 2012

Type: article

Abstract: Myleodysplastic syndromes (MDS) are pre-malignant hematopoietic diseases that can progress to acute myeloid leukemia (AML) progression in conjunction with changes in immune function. In this model of leukemia evolution, the expansion of immunosuppressive regulatory T cells (Tregs) contributes to immune escape. Here, we discuss the importance of Treg-memory phenotype switching as a poor prognostic indicator in MDS.

Source: OncoImmunology

DOI: 10.4161/onci.22654

Authors: Adam W. Mailloux, Pearlie K. Epling-Burnette

Institutions: Moffitt Cancer Center, James A. Haley Veterans' Hospital

Language: English

Topic: Acute Myeloid Leukemia Research

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,913