Work

Tumor Evolution in Response to Chemotherapy: Phenotype versus Genotype

Year: 2014

Type: article

Abstract: In this issue of Cell Reports, Almendro et al. report one of the first comprehensive studies on the intratumor heterogeneity of cell phenotypes and genotypes before and after chemotherapy in breast cancer. These data challenge the concept of genetic population bottlenecks and suggest that cellular phenotypes play an important role in developing resistance to therapy.

Source: Cell Reports

DOI: 10.1016/j.celrep.2014.01.035

Author: Nicholas E. Navin

Institution: The University of Texas MD Anderson Cancer Center

Language: English

Topic: Cancer Genomics and Diagnostics

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $5,620