Work

Special HATs for special occasions: linking histone acetylation to chromatin assembly and gene activation

Year: 1996

Type: review

Abstract: Post-translational acetylation of the core histone amino-terminal tails has long been associated with both chromatin assembly and the regulation of gene expression. The recent identification and cloning of histone acetyltransferase genes represents a significant breakthrough in our understanding of how specific acetylation states are established. Ongoing characterization of these enzymes and their molecular cohorts supports a direct role for acetylation in a signaling pathway that modulates chromatin structure to create new patterns of transcription.

Source: Current Opinion in Genetics & Development

DOI: 10.1016/s0959-437x(96)80048-7

Authors: James E Brownell, C David Allis

Institution: University of Rochester

Language: English

Topic: Genomics and Chromatin Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $4,200

Funder: Northwestern University Transportation Center