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CD25+ Regulatory T CELL-Depleted Donor Lymphocyte Infusion for Relapse After Allogeneic Transplantation – A PHASE 1 Study

Year: 2013
Type: article
Study design: Clinical Trial
Abstract: Donor CD4+CD25+FOXP3+ regulatory T cells (Treg) are capable of suppressing immune-mediated graft-versus-leukemia (GvL) and graft-versus-host disease (GvHD) responses. We undertook a dose-finding phase 1 study of CD25-depleted donor lymphocyte infusions (DLI) to treat post-transplantation relapse.
DOI: 10.1016/j.bbmt.2012.11.074
Authors: Sarah Nikiforow, Haesook Kim, Grace Kao, Marie-Michele Sainvil, Sean M. McDonough, Philippe Armand, Vincent T. Ho, Edwin P. Alyea, Corey Cutler, Jerome Ritz, Joseph H. Antin, Robert J. Soiffer, John Koreth
Language: English
Subfield: Hematology
Field: Medicine
Open Access status: hybrid
Estimated APC paid: $3,650
OpenAlex ID: W1987410101
FWCI: 0.214
Cites:
Cited by: 1
Related to: 10