Work

The transfer of protons in water wires inside proteins

Year: 2003

Type: review

Abstract: The translocation of protons across membrane proteins is an essential phenomenon in biology. Only in recent years however, have we started to study in detail some of the basic features of proton transfer in water molecules inside proteins at the single molecule level. Due to their truly unique features, gramicidin-based ion channels have been used to probe proton transfer in both experimental and computational fronts. In this article, some of the new experimental findings on proton transfer in water molecules inside proteins will be reviewed. The results, their interpretations, and the perspectives toward the understanding of structure-function illations of proton transfer in proteins are discussed.

Source: Frontiers in bioscience

DOI: 10.2741/1192

Author: Samuel Cukierman

Institutions: Loyola University Medical Center, Loyola University Chicago, Loyola Medicine

Language: English

Topic: Nanopore and Nanochannel Transport Studies

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: bronze

Funders: National Institutes of Health, National Institute of General Medical Sciences

Award: G4936502799