Work

A conserved RGD (Arg-Gly-Asp) motif in the transferrin receptor is required for binding to transferrin

Year: 1999

Type: article

Abstract: The transferrin receptor contains a highly conserved Arg-Gly-Asp (RGD) sequence in the C-terminal region where transferrin is thought to bind. RGD sequences are commonly involved in cell adhesion. This sequence is crucial for transferrin binding, suggesting possible evolutionary links between molecules mediating iron uptake and cell adhesion.

Source: Biochemical Journal

DOI: 10.1042/0264-6021:3410011

Authors: Valentina DUBLJEVIC, Adnan SALI, James W. GODING

Institution: The Alfred Hospital

Language: English

Topic: Iron Metabolism and Disorders

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

Open Access status: bronze

OpenAlex ID: W1987489188

FWCI: 2.836

Cites: 25

Cited by: 63

Related to: 10