Quantifying Pituitary-Adrenal Dynamics and Deconvolution of Concurrent Cortisol and Adrenocorticotropic Hormone Data by Compressed Sensing
Year: 2015
Type: article
Abstract: Pulsatile release of cortisol from the adrenal glands is governed by pulsatile release of adrenocorticotropic hormone (ACTH) from the anterior pituitary. In return, cortisol has a negative feedback effect on ACTH release. Simultaneous recording of ACTH and cortisol is not typical, and determining the number, timing, and amplitudes of pulsatile events from simultaneously recorded data is challenging because of several factors: 1) stimulator ACTH pulse activity, 2) kinematics of ACTH and cortisol, 3) the sampling interval, and 4) the measurement error. We model ACTH and cortisol secretion simultaneously using a linear differential equations model with Gaussian errors and sparse pulsatile events as inputs to the model. We propose a novel framework for recovering pulses and parameters underlying the interactions between ACTH and cortisol. We recover the timing and amplitudes of pulses using compressed sensing and employ generalized cross validation for determining the number of pulses. We analyze serum ACTH and cortisol levels sampled at 10-min intervals over 24 h from ten healthy women. We recover physiologically plausible timing and amplitudes for these pulses and model the feedback effect of cortisol. We recover 15 to 18 pulses over 24 h, which is highly consistent with the results of another cortisol data analysis approach. Modeling the interactions between ACTH and cortisol allows for accurate quantification of pulsatile events, and normal and pathological states. This could lay the basis for a more physiologically-based approach for administering cortisol therapeutically. The proposed approach can be adapted to deconvolve other pairs of hormones with similar interactions.
Language: English
Subfield: Signal Processing
Field: Computer Science
Domain: Physical Sciences
Open Access status: green
Funders: National Science Foundation, National Aeronautics and Space Administration, National Space Biomedical Research Institute, National Institutes of Health, U.S. Public Health Service, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Center for Research Resources
Awards: Characterization of a Complex Involved In Rothmund-Thomson Syndrome, G1519142367, G1534012568, G1704079599, Sleep Duration Required to Restore Performance during Chronic Sleep Restriction, EFRI-ARESCI: Foundations for Reconfigurable and Autonomous Cyber-Physical Systems: Cyber-Cities and Cyber-Universities, STATISTICAL ANALYSIS OF HUMAN CIRCADIAN RHYTHMS, G2725714246, Redesigning General Anesthesia, A Systems Neuroscience Approach for the Study of General Anesthesia, Harvard Clinical and Translational Science Center (UL1), G3499677803, REGULATION OF ADRENAL FUNCTION IN FIBROMYALGIA, General Clinical Research Center, G4420413849, Human circadian sensitivity to very short light pulses, Collaborative Research: CDI-Type II: Discovery of Succinct Dynamical Relationships in Large-Scale Biological Data Sets, Sleep, Aging and Circadian Rhythm Disorders, Sleep duration required to restore performance during chronic sleep restriction, G5875411954, REHABILITATION OF CIRCADIAN BLINDNESS IN OLDER PEOPLE, G6925966499, NATIONAL SPACE BIOMEDICAL RESEARCH INSTITUTE, G8188376246, G8340082409, Aldosterone and Cardiovascular Disease: Research and Mentoring Program, G9000118385, G9000328236
OpenAlex ID: W1987809657