Work

Pseudomonas aeruginosa Cell-to-Cell Signaling Is Required for Virulence in a Model of Acute Pulmonary Infection

Year: 2000

Type: article

Abstract: Cell-to-cell signaling controls many virulence genes in Pseudomonas aeruginosa. We tested the virulence of las and rhl quorum-sensing mutants in neonatal mice. A lasI rhlI double mutant was nearly avirulent, and the respective single mutant strains were reduced in virulence compared with the wild-type strain. Quorum sensing plays a role in P. aeruginosa pneumonia in neonatal mice.

Source: Infection and Immunity

DOI: 10.1128/iai.68.7.4331-4334.2000

Authors: James P. Pearson, Matthew Feldman, Barbara H. Iglewski, Alice Prince

Institutions: University of Rochester Medicine, University of Rochester, Columbia University

Language: English

Topic: Bacterial biofilms and quorum sensing

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, U.S. Public Health Service, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases