Work

Malignant Progression in Two Children with Multiple Osteochondromas

Year: 2010

Type: article

Abstract: Multiple Osteochondromas (MO) is a disease of benign bony growths with a low incidence of malignant transformation. Secondary chondrosarcoma in children is rare even in children with MO. Making a diagnosis of malignancy in low-grade cartilage tumors is challenging and requires consideration of clinical, radiographic, and histopathological factors. We report two cases of skeletally immature patients with MO who presented with rapidly enlarging and radiographically aggressive lesions consistent with malignant transformation. Both underwent allograft reconstruction of the involved site with no signs of recurrence or metastatic disease at a minimum of four-year follow-up.

Source: Sarcoma

DOI: 10.1155/2010/417105

Authors: Gregory A. Schmale, Douglas S. Hawkins, Joe Rutledge, Ernest U. Conrad

Institutions: Seattle Children's Hospital, University of Washington

Language: English

Topic: Bone Tumor Diagnosis and Treatments

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $820