Work

Lack of association of the apoE4 allele with hippocampal sclerosis dementia

Year: 1996

Type: article

Abstract: We determined the apolipoprotein E4 (apoE) genotype in 12 cases of autopsy-confirmed hippocampal sclerosis dementia (HSD), a disorder characterized pathologically by neuronal degeneration, predominantly of temporal lobe structures, without senile plaques or neurofibrillary tangles. The frequency of the apoE4 allele in HSD was 12.5%, similar to that of a control population and significantly different from the approximately 40% found in Alzheimer's disease (AD) (P < 0.001). These observations suggest that apoE4 is not a risk factor for HSD.

Source: Neuroscience Letters

DOI: 10.1016/0304-3940(96)12331-4

Authors: Juan C. Troncoso, Claudia H. Kawas, Craig K. Chang, Marshal F. Folstein, John C. Hedreen

Institutions: Johns Hopkins University, Johns Hopkins Medicine, National Institute on Aging, Massachusetts Institute of Technology

Language: English

Topic: Alzheimer's disease research and treatments

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,430