Work

Dendritic Cells, Tolerance Induction and Transplant Outcome

Year: 2002

Type: review

Abstract: Dendritic cells (DC) have been viewed traditionally as ‘foes’ that instigate the rejection process. More recently, they have gained considerable attention as antigen (Ag)‐presenting cells (APC) that are also capable of induction/maintenance of immunologic tolerance (1–3). This contemporary view of DC, reflects new insights into how these cells regulate T cell responses. Herein we review accumulating evidence that manipulation of DC can suppress Ag‐specific immune responses and build a case that this may provide a novel approach to therapy of allograft rejection.

Source: American Journal of Transplantation

DOI: 10.1034/j.1600-6143.2002.20403.x

Authors: P. Toby H. Coates, Angus W. Thomson

Institution: University of Pittsburgh Medical Center

Language: English

Topic: Immunotherapy and Immune Responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,300