Work

The Complex Relationship between Liver Cancer and the Cell Cycle: A Story of Multiple Regulations

Year: 2014

Type: article

Abstract: The liver acts as a hub for metabolic reactions to keep a homeostatic balance during development and growth. The process of liver cancer development, although poorly understood, is related to different etiologic factors like toxins, alcohol, or viral infection. At the molecular level, liver cancer is characterized by a disruption of cell cycle regulation through many molecular mechanisms. In this review, we focus on the mechanisms underlying the lack of regulation of the cell cycle during liver cancer, focusing mainly on hepatocellular carcinoma (HCC). We also provide a brief summary of novel therapies connected to cell cycle regulation.

Source: Cancers

DOI: 10.3390/cancers6010079

Authors: Xavier Bisteau, Matias Caldez, Philipp Kaldis

Institutions: Agency for Science, Technology and Research, Institute of Molecular and Cell Biology, National University of Singapore

Language: English

Topic: Cancer-related Molecular Pathways

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,499