Work

Active Conservation of Noncoding Sequences Revealed by Three-Way Species Comparisons

Year: 2000
Type: preprint
Abstract: Human and mouse genomic sequence comparisons are being increasingly used to search for evolutionarily conserved gene regulatory elements. Large-scale human–mouse DNA comparison studies have discovered numerous conserved noncoding sequences of which only a fraction has been functionally investigated A question therefore remains as to whether most of these noncoding sequences are conserved because of functional constraints or are the result of a lack of divergence time. [The sequence data described in this paper have been submitted to the GenBank data library under accession nos. AF276990 .]
Language: English
Open Access status: bronze
Award: G439005279
OpenAlex ID: W1988422919
Cites: 11
Cited by: 309
Related to: 10