Work

Targeting protein−protein interfaces using macrocyclic peptides

Year: 2015

Type: review

Abstract: Protein-protein interactions (PPIs) are critical in numerous biological processes including signaling transduction, function regulations, and disease development. To regulate PPIs has been thought to be challenging due to their highly dynamic and expansive interfacial areas. Nonetheless, successful examples have been reported of targeting PPIs using small molecules, peptides, and proteins. Peptides, especially macrocyclic peptides have proven to be a particularly useful tool to inhibit PPIs for their exquisite potency, stability and selectivity. Herein we review the recent developments of this area of research, focusing on the macrocyclic peptides isolated from natural products, identified from library screening, and rationally designed based on structures, as PPI regulators.

Source: Biopolymers

DOI: 10.1002/bip.22625

Authors: Meng Gao, Kui Cheng, Hang Yin

Institutions: Tsinghua University, University of Colorado Boulder

Language: English

Topic: Chemical Synthesis and Analysis

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Science Foundation, Tsinghua University, National Institutes of Health, National Institute of General Medical Sciences