Work

Tissue engineering by self-assembly

Year: 2011

Type: article

Abstract: A long-standing limitation in tissue engineering has been the dogmatic reliance on synthetic scaffolds for building tissues with significant mechanical functions despite their deleterious effects (inflammation, scarring, infection, etc.). Tissue engineering by self-assembly (TESA) is a novel approach that relies on the cell's ability to produce natural extracellular matrix TESA can be used to produce structures that have physiological strength and are not recognized as foreign in vivo. We have developed a tissue-engineered blood vessel that has shown great promise as an arteriovenous shunt. Here, we review our journey from bench-top to bedside and discuss future applications of the TESA approach.

Source: Materials Today

DOI: 10.1016/s1369-7021(11)70117-1

Authors: Marissa Peck, Nathalie Dusserre, Todd N. McAllister, Nicolas L'Heureux

Institutions: Cytograft Tissue Engineering (United States), Saint Joseph’s Translational Research Institute

Language: English

Topic: Tissue Engineering and Regenerative Medicine

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $6,070