Work

Nanofibrous Bio‐inorganic Hybrid Structures Formed Through Self‐Assembly and Oriented Mineralization of Genetically Engineered Phage Nanofibers

Year: 2010

Type: article

Abstract: Filamentous M13 phage is genetically engineered to become anionic by fusing a negatively charged peptide to its major coat protein (pVIII). The cationic precursors of hydroxylapatite (HAP) such as Ca2+ ions induce the self-assembly of the negatively charged phage into a nanofibrous structure in the presence of anionic precursors such as PO43− ions. The cationic and anionic precursors are accumulated within the nanofibrous structure, leading to the formation of oriented nanocrystalline HAP.

Source: Small

DOI: 10.1002/smll.201001108

Authors: Tao He, Gopal Abbineni, Binrui Cao, Chuanbin Mao

Institution: University of Oklahoma

Language: English

Topic: Bone Tissue Engineering Materials

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: bronze

Funders: National Science Foundation, National Heart, Lung, and Blood Institute, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institute of Biomedical Imaging and Bioengineering

Awards: G2253927029, Bone-seeking and cell-targeting non-viral vectors for BMP-2 gene delivery, Phage-inspired nanoparticles with genetically tunable target-specificity, Phage-Mimetic Nanorods for Targeted Breast Cancer Treatment