Work

Amplitude-masked photoacoustic wavefront shaping and application in flowmetry

Year: 2014

Type: article

Abstract: Optical-resolution photoacoustic flowmetry (PAF) allows noninvasive single-cell flow measurements. However, its operational depth is limited by optical diffusion, which prevents focusing beyond shallow depths in scattering media, as well as reducing the measurement signal-to-noise ratio (SNR). To overcome this limitation, we used binary-amplitude wavefront shaping to enhance light focusing in the presence of scattering. Here, the transmission modes that contributed constructively to the intensity at the optical focus were identified and selectively illuminated, resulting in a 14-fold intensity increase and a corresponding increase in SNR. This technique can potentially extend the operational depth of optical-resolution PAF beyond 1 mm in tissue.

Source: Optics Letters

DOI: 10.1364/ol.39.005499

Authors: Jian Wei Tay, Jinyang Liang, Lihong V. Wang

Institution: Washington University in St. Louis

Language: English

Topic: Photoacoustic and Ultrasonic Imaging

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: bronze

Funders: National Institutes of Health, National Cancer Institute, National Institute of Biomedical Imaging and Bioengineering, National Center for Chronic Disease Prevention and Health Promotion

Awards: Photon tunneling: Shedding new light on biomedicine, G1952371934, Photoacoustic endoscopy of Barretts esophagus, In vivo imaging of single circulating cells, PHOTOACOUSTIC MICROSCOPY OF NEOVASCULARIZATION IN RENAL CANCER GROWTH AND THERAPY