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The Synergistic Effects of HIV, Diabetes, and Aging on Cognition

Year: 2014

Type: article

Abstract: Thanks to highly active antiretroviral therapy, many people infected with HIV will likely live into old age. Although this is a welcome prognosis, new issues are emerging that may complicate the ability to successfully age in this clinical population. HIV and aging independently are related to cognitive impairments, so there are concerns that those aging with HIV may be more at risk of such cognitive impairments. Moreover, highly active antiretroviral therapy itself can create metabolic disorders, such as prediabetes and/or frank type 2 diabetes, which have also been linked to poorer cognitive functioning. Thus, concerns increase that, as people age with HIV and develop comorbid metabolic disorders that may lead to type 2 diabetes, they will be at triple risk of developing cognitive impairments that can impair everyday functioning and reduce quality of life. This article explores these issues and provides implications for practice and research.

Source: Journal of Neuroscience Nursing

DOI: 10.1097/jnn.0000000000000074

Authors: David E. Vance, Pariya L. Fazeli, Joan E. Dodson, Michelle Ackerman, Michele Talley, Susan J. Appel

Institutions: University of Alabama at Birmingham, University of California San Diego, University of Alabama

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institute on Aging, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute on Minority Health and Health Disparities