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The hydrolysis of ATP that accompanies actin polymerization is essentially irreversible

Year: 1988

Type: article

Abstract: The hydrolysis of ATP that accompanies the polymerization of actin occurs on the F-actin subsequent to the addition of the G-ATP-actin subunit to the elongating filament. We now show that this ATP hydrolysis is essentially irreversible. Thus, a large decrease in free energy occurs at the cleavage step, F-ATP-actin----F-ADP-Pi-actin.

Source: FEBS Letters

DOI: 10.1016/0014-5793(88)81264-x

Authors: Marie-France Carlier, Dominique Pantaloni, John A. Evans, Peter K. Lambooy, Edward D. Korn, Martin R. Webb

Institutions: Centre National de la Recherche Scientifique, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute for Medical Research

Language: English

Topic: Cellular Mechanics and Interactions

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

OpenAlex ID: W1988663097

FWCI: 1.25

Cites: 25

Cited by: 60

Related to: 10