Year: 2009
Type: article
Abstract: Background Soluble guanylate cyclase (sGC) is the signal transduction enzyme most responsible for mediating the effects of nitric oxide by producing cyclic guanosine monophosphate (cGMP) from guanosine triphosphate (GTP). NOcGMP signaling is vital to proper cardiovascular function. Deficiencies in the production of either NO or cGMP contribute to cardiovascular disorders. Therapies designed to increase in vivo NO levels (such as organic nitrates) have well documented clinical limitations due to drug tolerance. Recently, a variety of NO-independent small molecule activators of sGC have been reported that activate nearly or as well as NO and have promising clinical activities. Previous results from our lab have shown that the secreted matrix protein thrombospondin-1 (TSP-1) binds to CD47 and potently inhibits NO stimulation of sGC.
Source: BMC Pharmacology
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W1988664338