Work

Computational analysis of the effect of valvular regurgitation on ventricular mechanics using a 3D electromechanics model

Year: 2015

Type: article

Abstract: Using a three-dimensional electromechanical model of the canine ventricles with dyssynchronous heart failure, we investigated the relationship between severity of valve regurgitation and ventricular mechanical responses. The results demonstrated that end-systolic tension in the septum and left ventricular free wall was significantly lower under the condition of mitral regurgitation (MR) than under aortic regurgitation (AR). Stroke work in AR was higher than that in MR. On the other hand, the difference in stroke volume between the two conditions was not significant, indicating that AR may cause worse pumping efficiency than MR in terms of consumed energy and performed work.

Source: The Journal of Physiological Sciences

DOI: 10.1007/s12576-014-0353-4

Authors: Ki Moo Lim, Seung-Bae Hong, Byong Kwon Lee, Eun Bo Shim, Natalia Trayanova

Institutions: Kumoh National Institute of Technology, Kangwon National University, Yonsei University, Yonsei University Health System, Johns Hopkins University

Language: English

Topic: Cardiac Valve Diseases and Treatments

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,900