Work

Hydrolytically Degradable Thiol–ene Hydrogels for Protein Release

Year: 2013

Type: article

Abstract: A new degradable PEG-diester-dinorbornene/PEG-triester-trithiol hydrogel was evaluated for protein release. The hydrogel polymerized rapidly with seconds of UV irradiation and subsequently hydrolytically degraded in aqueous buffer over the course of approximately 3 weeks. Further, the hydrogel enabled the encapsulation and release of a model protein, bovine serum albumin (BSA), over 7 days with ~ 90% released at 48 h. This study serves as a proof-of-concept for the creation of hydrolytically degradable, PEG-ester-thiol-based hydrogels by a photoinitiated step growth mechanism for protein release. With this approach, degradation and release rates could be tuned by varying the monomer molecular weight and functionality in future studies.

Source: Macromolecular Symposia

DOI: 10.1002/masy.201200133

Authors: Matthew S. Rehmann, Andrew C. Garibian, April M. Kloxin

Institution: University of Delaware

Language: English

Topic: Hydrogels: synthesis, properties, applications

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Institute of General Medical Sciences, National Center for Research Resources

Awards: Molecular Design of Advanced Biomaterials, Chemistry-Biology Interface (CBI) NIH T32 Training Grant