Work

A novel member of the serpin superfamily is encoded on a circular plasmid‐like DNA species isolated from rabbit cells

Year: 1986

Type: article

Abstract: A novel member of the serpin family of serine protease inhibitors is presented. A plasmid-like DNA was isolated from rabbit cells by its homology to the genome of Shope fibroma virus (SFV), a tumorigenic poxvirus of rabbits, and was shown elsewhere to encode a serpin-like protein [(1986) Mol. Cell. Biol. 6, 265-276]. Although significant DNA homology exists between the rabbit plasmid serpin open reading frame and the SFV terminal inverted repeat DNA there is no intact serpin counterpart encoded by this region of the SFV genome. The alignment of the novel plasmid-borne polypeptide with the serpin family of proteins confirms its status within this group.

Source: FEBS Letters

DOI: 10.1016/0014-5793(86)80023-0

Authors: C. Upton, R.W. Carrell, G. McFadden

Institutions: University of Alberta, Addenbrooke's Hospital

Language: English

Topic: Protease and Inhibitor Mechanisms

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze