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Tryptase Is Not Cleared by the Kidneys into the Urine

Year: 2009

Type: article

Abstract: BACKGROUND: Patients with chronic kidney disease have been reported to have increased concentrations of blood tryptase. Detection of tryptase in the urine of healthy subjects has been reported. OBJECTIVE: The objective is to determine whether tryptase is indeed cleared by the kidneys. METHODS: Blood and urine collections were performed in healthy and systemic mastocytosis subjects. Total and mature tryptase concentrations in blood and total tryptase concentrations in urine were determined. RESULTS: Total tryptase levels in urine were below the limit of detection in both healthy subjects and those with systemic mastocytosis, even after concentrating the urine 10-fold. Thus, both mature and protryptase levels in urine are <0.2 ng/ml. CONCLUSION: Tryptase is not cleared by the kidneys into the urine.

Source: International Archives of Allergy and Immunology

DOI: 10.1159/000260080