Year: 2012
Type: article
Abstract: Small molecules that modulate histone acetylation by targeting key enzymes mediating this posttranslational modification – histone acetyltransferases and histone deacetylases – are validated chemotherapeutic agents for the treatment of cancer. This area of research has seen a rapid increase in interest in the past decade, with the structurally diverse natural products-derived compounds at its forefront. These secondary metabolites from various biological sources target this epigenetic modification through distinct mechanisms of enzyme regulation by utilizing a diverse array of pharmacophores. We review the discovery of these compounds and discuss their modes of inhibition together with their downstream biological effects. Keywords: Histone acetylation, histone deacetylases, histone acetyltransferases, natural products, secondary metabolites, Natural Products, chemotherapeutic agents, epigenetic modification, enzyme regulation, DNA
Source: Current Drug Targets
Authors: Lilibeth A. Salvador, Hendrik Luesch
Institution: University of Florida
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
Awards: G1894278759, G9000342116
OpenAlex ID: W1989102871