Work

Silver metallation of hen egg white lysozyme: X-ray crystal structure and NMR studies

Year: 2011

Type: article

Abstract: The X-ray crystal structure, NMR binding studies, and enzyme activity of silver(I) metallated hen egg white lysozyme are presented. Primary bonding of silver is observed through His15 with secondary bonding interactions coming from nearby Arg14 and Asp87. A covalently bound nitrate completes a four coordinate binding pocket.

Source: Chemical Communications

DOI: 10.1039/c1cc15908a

Authors: Matthew J. Panzner, Stephanie M. Bilinovich, Wiley J. Youngs, Thomas C. Leeper

Institution: University of Akron

Language: English

Topic: Enzyme Structure and Function

Subfield: Materials Chemistry

Field: Materials Science

Domain: Physical Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Awards: G1543795771, Collaborative Research: Polymeric Drug Delivery Systems and Biofilms in the Lung