Work

Amplification of signaling via cellular allosteric relay and protein disorder

Year: 2009

Type: article

Abstract: Determining changes in the composition of cell populations is made possible by technologies like single-cell transcriptomics, CyTOF, and microbiome sequencing. However, existing methods for differential abundance do not model some ...Cellular omics such as single-cell genomics, proteomics, and microbiomics allow the characterization of tissue and microbial community composition, which can be compared between conditions to identify biological drivers. This strategy has been critical to ...

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.0903024106

Authors: Buyong Ma, Ruth Nussinov

Institutions: Frederick National Laboratory for Cancer Research, National Cancer Institute, Center for Cancer Research, Tel Aviv University

Language: English

Topic: Protein Structure and Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: Fonds De La Recherche Scientifique - FNRS, National Institutes of Health, National Cancer Institute

Awards: G1356092923, DCTD Computer Support, G1799052500