Thymosin beta-10 is Aberrantly Expressed in Pancreatic Cancer and Induces JNK Activation
Year: 2009
Type: article
Abstract: Thymosin beta-10 (T beta 10) has been shown to be associated with several cancers; however, its role in pancreatic cancer is not understood. The expression of T beta 10 was determined by immunohistochemistry and real-time polymerase chain reaction. The phosphorylation of JNK and the cytokine secretion was determined by using the Bio-Plex phosphoprotein and cytokines assays. Pancreatic cancer tissues and cells expressed higher amounts of T beta 10 than normal surrounding tissues and human pancreatic duct epithelial cells. Exogenous T beta 10 caused the phosphorylation of JNK and increased the secretion of cytokines interleukin (IL)-7 and IL-8 in BxPC-3 cells. T beta 10 might be a promising marker and a novel therapeutic target for pancreatic cancer.
Source: Cancer Investigation
Authors: Min Li, Yuqing Zhang, Qihui Zhai, Louis W. Feurino, William E. Fisher, Changyi Chen, Qizhi Yao
Institutions: Baylor College of Medicine, Houston Methodist
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: TARGETED MUTAGENESIS OF NEUROENDOCRINE REGULATORY GENES, Tissue engineering of small diameter vascular graft, Influenza HA in SHIV VLPS for mucosal vaccination, Ginkgo Biloba Enhances Therapeutic HIV Vaccination, G6170213943, G640625107, G675304304, Effects of HAART drugs on endothelial dysfunction of pu*
OpenAlex ID: W1989484669