P3‐096: Cerebrospinal fluid biomarkers predict development of subjective cognitive impairment over three years in healthy elderly
Year: 2008
Type: article
Study design: Observational Study
Abstract: Cerebrospinal fluid (CSF) biomarkers show a specific pattern of change in Alzheimer's disease (AD) and predict progression from mild cognitive impairment to AD with good accuracy. It has been suggested that these changes precede cognitive decline and hence would be evident already in preclinical stages. The aim of the study was to investigate if cognitive decline in healthy elderly are preceded by changes in CSF biomarkers' levels. CSF analysis was performed on 57 cognitively healthy elderly at baseline. They were then evaluated with cognitive tests and assessment scales after 3 years. Development of subjective memory impairment affecting quality of life (memQoL) after 3 years were correlated with low CSF β-amyloid1–42 (Aβ42) at baseline (p <0.05). CSF Aβ42 together with CSF phosphorylated tau (P-tau) best predicted development of pathological memQoL with sensitivity of 71.4 %, specificity of 75.7 % and an OR of 9.5 (p <0.001). Furthermore low Aβ42 levels were associated with inability to live in regular housing and a worse mini mental status examination (MMSE) score (p <0.05), whereas the individuals developing pathological memQoL were slower in cognitive speed (p <0.01) compared to those cognitively stable. The AD-associated combination of low CSF Aβ42 and high CSF P-tau predicted subjective cognitive decline over 3 year in healthy elderly. Our results suggest that AD-related pathological changes in the brain might be detectable already in a clinically normal elderly population.
Source: Alzheimer s & Dementia
Institutions: Lund University, Sahlgrenska University Hospital
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W1989924240