Work

From streaming‐potentials to shear stress: 25 years of bone cell mechanotransduction

Year: 2008

Type: review

Abstract: Mechanical loads are vital regulators of skeletal mass and architecture as evidenced by the increase in bone formation following the addition of exogenous loads and loss of bone mass following their removal. While our understanding of the molecular mechanisms by which bone cells perceive changes in their mechanical environment has increased rapidly in recent years, much remains to be learned. Here, we outline the effects of interstitial fluid flow, a potent biophysical signal induced by the deformation of skeletal tissue in response to applied loads, on bone cell behavior. We focus on the molecular mechanisms by which bone cells are hypothesized to perceive interstitial fluid flow, the cell signaling cascades activated by fluid flow, and the use of this signal in tissue engineering protocols.

Source: Journal of Orthopaedic Research®

DOI: 10.1002/jor.20723

Authors: Ryan C. Riddle, Henry J. Donahue

Institutions: University of Alabama at Birmingham, Pennsylvania State University, Penn State Milton S. Hershey Medical Center

Language: English

Topic: Cellular Mechanics and Interactions

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funders: University of Pennsylvania, Pennsylvania State University, National Institute on Aging, National Institute of Arthritis and Musculoskeletal and Skin Diseases

Awards: Gap Junction and Bone Cell Responses to Physical Signals, Gap Junction and Bone Cell Response to Physical Signals