Work

Sororin is a master regulator of sister chromatid cohesion and separation

Year: 2012

Type: review

Abstract: The maintenance of sister chromatid cohesion from S phase to the onset of anaphase relies on a small but evolutionarily conserved protein called Sororin. Sororin is a phosphoprotein and its dynamic localization and function are regulated by protein kinases, such as Cdk1/cyclin B and Erk2. The association of Sororin with chromatin requires cohesin to be preloaded to chromatin and modification of Smc3 during DNA replication. Sororin antagonizes the function of Wapl in cohesin releasing from S to G 2 phase and promotes cohesin release from sister chromatid arms in prophase via interaction with Plk1. This review focuses on progress of the identification and regulation of Sororin during cell cycle; role of post-translational modification on Sororin function; role of Sororin in the maintenance and resolution of sister chromatid cohesion; and finally discusses Sororin's emerging role in cancer and the potential issues that need be addressed in the future.

Source: Cell Cycle

DOI: 10.4161/cc.20241

Authors: Nenggang Zhang, Debananda Pati

Institutions: Baylor College of Medicine, Texas Children's Hospital

Language: English

Topic: Microtubule and mitosis dynamics

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funders: Simmons Family Foundation, Virginia and L.E. Simmons Family Foundation, National Cancer Institute

Awards: G3276359457, G4067336497, Mitotic Regulation of Apoptosis in Leukemia