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Animal Models of GWAS-Identified Type 2 Diabetes Genes

Year: 2013
Type: review
Abstract: More than 65 loci, encoding up to 500 different genes, have been implicated by genome-wide association studies (GWAS) as conferring an increased risk of developing type 2 diabetes (T2D). Whilst mouse models have in the past been central to understanding the mechanisms through which more penetrant risk genes for T2D, for example, those responsible for neonatal or maturity-onset diabetes of the young, only a few of those identified by GWAS, notably TCF7L2 and ZnT8/SLC30A8, have to date been examined in mouse models. We discuss here the animal models available for the latter genes and provide perspectives for future, higher throughput approaches towards efficiently mining the information provided by human genetics.
DOI: 10.1155/2013/906590
Language: English
Subfield: Genetics
Open Access status: gold
Estimated APC paid: $2,760
Funders: Wellcome Trust, European Federation of Pharmaceutical Industries and Associations, Royal Society, Diabetes UK, European Commission, European Foundation for the Study of Diabetes, Innovative Medicines Initiative, Medical Research Council
Awards: G1073258374, G119964413, G1732308444, Understanding pancreatic beta cell dysfunction in diabetes., Roles of GWA genes in controlling pancreatic beta cell function and mass., G2040450235, G3207356259, G3555667338, G393177772, G5702163051, G6100787592, G7727718855, G8072012048, G9000085185
OpenAlex ID: W1990332932
FWCI: 0.849
Cites: 142
Cited by: 33
Related to: 10