Learning from Nature to Improve the Heat Generation of Iron-Oxide Nanoparticles for Magnetic Hyperthermia Applications
Year: 2013
Type: article
Abstract: The performance of magnetic nanoparticles is intimately entwined with their structure, mean size and magnetic anisotropy. Besides, ensembles offer a unique way of engineering the magnetic response by modifying the strength of the dipolar interactions between particles. Here we report on an experimental and theoretical analysis of magnetic hyperthermia, a rapidly developing technique in medical research and oncology. Experimentally, we demonstrate that single-domain cubic iron oxide particles resembling bacterial magnetosomes have superior magnetic heating efficiency compared to spherical particles of similar sizes. Monte Carlo simulations at the atomic level corroborate the larger anisotropy of the cubic particles in comparison with the spherical ones, thus evidencing the beneficial role of surface anisotropy in the improved heating power. Moreover we establish a quantitative link between the particle assembling, the interactions and the heating properties. This knowledge opens new perspectives for improved hyperthermia, an alternative to conventional cancer therapies.
Source: Scientific Reports
DOI: 10.1038/srep01652
Authors: Carlos Martinez-Boubeta, Konstantinos Simeonidis, Antonios Makridis, Makis Angelakeris, Oscar Iglesias, Pablo Guardia, Andreu Cabot, Lluis Yedra, Sonia Estradé, Francesca Peiró, Zineb Saghi, Paul A. Midgley, Iván Conde-Leborán, David Serantes, Daniel Baldomir
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $2,690
Awards: G2600951886, G6986350915
OpenAlex ID: W1990396565