Work

Social Defeat as an Animal Model for Depression

Year: 2014

Type: review

Abstract: Depression is one of the most disabling medical conditions in the world today, yet its etiologies remain unclear and current treatments are not wholly effective. Animal models are a powerful tool to investigate possible causes and treatments for human diseases. We describe an animal model of social defeat as a possible model for human depression. We discuss the paradigm, behavioral correlates to depression, and potential underlying neurobiological mechanisms with an eye toward possible future therapies.

Source: ILAR Journal

DOI: 10.1093/ilar/ilu002

Authors: F. Hollis, M. Kabbaj

Institutions: Florida State University, École Polytechnique Fédérale de Lausanne

Language: English

Topic: Stress Responses and Cortisol

Subfield: Behavioral Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W1990418876