Work

The IGF‐1 receptor in cancer biology

Year: 2003

Type: review

Abstract: The type 1 insulin-like growth factor receptor (IGF-1R) plays an important role in the establishment and maintenance of the transformed phenotype. It also has a strong antiapoptotic activity and has a significant influence on the control of cell and body size. Downregulation of the IGF-1R leads to massive apoptosis of cancer cells. These characteristics make it an attractive target for anticancer therapy.

Source: International Journal of Cancer

DOI: 10.1002/ijc.11487

Authors: Renato Baserga, Francesca Peruzzi, Krysztof Reiss

Institutions: Thomas Jefferson University, Sidney Kimmel Cancer Center, Temple University

Language: English

Topic: Growth Hormone and Insulin-like Growth Factors

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institutes of Health, National Institute on Aging