Work

The Prominent Role of Neutrophils during the Initial Phase of Infection byLeishmaniaParasites

Year: 2009

Type: review

Abstract: Neutrophils are rapidly and massively recruited to the site of Leishmania inoculation, where they phagocytose the parasites, some of which are able to survive within these first host cells. Neutrophils can thus provide a transient safe shelter for the parasites, prior to their entry into macrophages where they will replicate. In addition, neutrophils release and synthesize rapidly several factors including cytokines and chemokines. The mechanism involved in their rapid recruitment to the site of parasite inoculation, as well as the putative consequences of their massive presence on the microenvironment of the focus of infection will be discussed in the context of the development of the Leishmania-specific immune response.

Source: BioMed Research International

DOI: 10.1155/2010/719361

Authors: Mélanie Charmoy, Floriane Auderset, Cindy Allenbach, Fabienne Tacchini-Cottier

Institutions: World Health Organization, University of Lausanne

Language: English

Topic: Research on Leishmaniasis Studies

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $2,680