Work

Cystatin C as a marker of cognitive function in elders: Findings from the health ABC study

Year: 2008

Type: article

Study design: Observational Study

Abstract: We determined whether serum cystatin C, a novel measure of kidney function that colocalizes with brain β‐amyloid, is associated with cognition among 3,030 elders. Those with high cystatin C (n = 445; 15%) had worse baseline scores on Modified Mini‐Mental State Examination or Digit Symbol Substitution Test (p ≤ 0.02) compared with those with intermediate/low level and 7 years greater decline (p ≤ 0.04). Incident cognitive impairment (decline ≥1.0 standard deviation) was greatest among those with high cystatin C (Modified Mini‐Mental State Examination: 38 vs 25%; adjusted odds ratio, 1.92; 95% confidence interval, 1.37–2.69; Digit Symbol Substitution: 38 vs 26%; odds ratio, 1.54; 95% confidence interval, 1.10–2.15). Ann Neurol 2008

Source: Annals of Neurology

DOI: 10.1002/ana.21383

Authors: Kristine Yaffe, Karla Lindquist, Michael G. Shlipak, Eleanor Simonsick, Linda Fried, Caterina Rosano, Suzanne Satterfield, Hal Atkinson, B. Gwen Windham, Manjula Kurella‐Tamura

Institutions: San Francisco VA Medical Center, University of California, San Francisco, National Institute on Aging, University of Pittsburgh, University of Tennessee Health Science Center, Wake Forest University Health Sciences, Wake Forest University

Language: English

Topic: Dementia and Cognitive Impairment Research

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute on Aging, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: DYNAMICS OF HEALTH,AGING, AND BODY COMPOSITION, DYNAMICS OF HEALTH, AGING, AND BODY COMPOSITION, G228277984, HEALTH ABC--COORDINATING UNIT, G3527306070, G3562729581, G5743352832, G5872676120, G5909482378, G6050059158, Cognitive Decline in Chronic Renal Insufficiency, G870807107, G945304896

OpenAlex ID: W1990574432

FWCI: 3.339

Cites: 23

Cited by: 130

Related to: 10