Work

Tetrazine–trans-cyclooctene ligation for the rapid construction of 18F labeled probes

Year: 2010

Type: article

Abstract: A radiolabeling method for bioconjugation based on the Diels-Alder reaction between 3,6-diaryl-s-tetrazines and an (18)F-labeled trans-cyclooctene is described. The reaction proceeds with exceptionally fast rates, making it an effective conjugation method within seconds at low micromolar concentrations.

Source: Chemical Communications

DOI: 10.1039/c0cc03078c

Authors: Zibo Li, Hancheng Cai, Matthew Hassink, Melissa L. Blackman, Richard C. D. Brown, Peter S. Conti, Joseph M. Fox

Institutions: University of Southern California, University of Delaware, University of Southampton

Language: English

Topic: Radiopharmaceutical Chemistry and Applications

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

Open Access status: green

Funder: National Center for Research Resources

Award: Molecular Design of Advanced Biomaterials

OpenAlex ID: W1990765611

FWCI: 11.22

Cites: 20

Cited by: 192

Related to: 10