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Erythropoietin: when liability becomes asset in neurovascular repair

Year: 2008

Type: article

Abstract: Erythropoietin (Epo) leads to the proliferation and differentiation of erythroid precursors, but is also involved in diverse nonhematopoietic biological functions. In this issue of the JCI, Chen, Smith, and colleagues demonstrate that the temporal expression of Epo is critical for determining whether physiological or pathological repair occurs following neurovascular retinal injury in the oxygen-induced retinopathy neonatal mouse model (see the related article beginning on page 526). The pleiotrophic properties of Epo make it a likely novel therapy for treatment of neurovascular damage, but the timing of its use must be carefully considered to prevent untoward effects.

Source: Journal of Clinical Investigation

DOI: 10.1172/jci34643

Authors: Maria B. Grant, Michael E. Boulton, Alexander V. Ljubimov

Institutions: University of Florida Health, University of Florida, The University of Texas Medical Branch at Galveston, Cedars-Sinai Medical Center, University of California, Los Angeles

Language: English

Topic: Erythropoietin and Anemia Treatment

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W1990784080

FWCI: 1.716

Cites: 41

Cited by: 23

Related to: 10