Work

POLE mutations as an alternative pathway for microsatellite instability in endometrial cancer: Implications for L ynch syndrome testing

Year: 2014

Type: editorial

Abstract: In endometrial cancer, the presence of polymerase ɛ (POLE) exonuclease domain mutations in immunohistochemically abnormal/microsatellite unstable/mutL homolog1‐unmethylated tumors may serve as a marker of somatic origin. These mutations may be important in making determinations and recommendations for mismatch repair gene mutation testing in women with endometrial cancer.

Source: Cancer

DOI: 10.1002/cncr.29057

Authors: Panagiotis A. Konstantinopoulos, Ursula A. Matulonis

Institution: Dana-Farber Cancer Institute

Language: English

Topic: Genetic factors in colorectal cancer

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W1990788312

Cites: 11

Cited by: 21

Related to: 10