Work

Toxicarioside B and toxicarioside C. New cardenolides isolated from Antiaris toxicaria latex-derived dart poison

Year: 1997

Type: article

Abstract: Bioassay-guided fractionation of the chloroform/methanol extract of a dart poison from Indonesian Borneo (Kalimantan), derived from Antiaris toxicaria latex, has led to the isolation of two new cardenolides, toxicarioside B [2] and toxicarioside C [3]. Structures for 2 and 3 were deduced by analysis of spectroscopic data; these materials are isomeric with toxicarioside A [1] previously isolated in our earlier work with the same poison. The bioassay employed to isolate cardenolides 2 and 3 involves inhibition of Na+K+-ATPase and mimics the suspected mode of action of these “cardiac-glycoside” toxins.

Source: Tetrahedron

DOI: 10.1016/s0040-4020(97)10174-0