Year: 2014
Type: review
Study designs: Systematic Review, Meta-Analysis
Abstract: BACKGROUND: Observational studies suggest that effects of vitamin D may be stronger for cancer mortality than for incidence. Yet, existing randomised controlled trials (RCTs) of vitamin D supplementation have limited power to examine the relationships as their primary end points are not cancer incidence or mortality. METHODS: Meta-analyses of RCTs of vitamin D supplementation and total cancer incidence and mortality were conducted. RESULTS: Over 2-7 years of duration, vitamin D supplementations had little effect on total cancer incidence (400-1100 IU per day, summary relative risk (RR)=1.00, 95% confidence interval (CI)=0.94-1.06, I(2)=0%; four RCTs with combined 4333 cases), but significantly reduced total cancer mortality (400-833 IU per day, summary RR=0.88, 95% CI=0.78-0.98, I(2)=0%, three RCTs with combined 1190 deaths). CONCLUSIONS: Over 2-7 years of duration, the benefit of vitamin D supplementation may be limited to cancer mortality.
Source: British Journal of Cancer
DOI: 10.1038/bjc.2014.294
Authors: N Keum, E Giovannucci
Institutions: Harvard University, Brigham and Women's Hospital
Language: English
Topic: Vitamin D Research Studies
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $5,190
OpenAlex ID: W1990859291