Work

Expansion of epidermal progenitors with high p63 phosphorylation during wound healing of mouse epidermis

Year: 2013

Type: article

Abstract: The transcription factor p63 plays an essential role in maintaining the proliferative potential of epidermal stem cells. We have shown recently that under homoeostatic conditions, phosphorylation of p63 increases during the early transition of stem cells to transit-amplifying cells in human epidermis. However, how p63 phosphorylation relates to the regenerative processes during wound healing remains unknown. In this study, we characterize epidermal cells that contribute to wound repair in mouse models using phosphorylated p63 as a marker for stem cell differentiation. Our studies reveal that epidermal progenitors with high p63 phosphorylation preferentially expand in response to wounding in both full-thickness wound and surface injury models. As phosphorylated p63 levels inversely correlate with the proliferative potential of epidermal progenitors, p63 phosphorylation may serve as a therapeutic target to modulate the function of these regenerative cells during wound healing.

Source: Experimental Dermatology

DOI: 10.1111/exd.12139

Authors: Daisuke Suzuki, Makoto Senoo

Institution: University of Pennsylvania

Language: English

Topic: Wound Healing and Treatments

Subfield: Rehabilitation

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Pennsylvania Department of Health, National Institute of Arthritis and Musculoskeletal and Skin Diseases