Work

Fast DNA Sequencing via Transverse Electronic Transport

Year: 2006

Type: article

Abstract: A rapid and low-cost method to sequence DNA would usher in a revolution in medicine. We propose and theoretically show the feasibility of a protocol for sequencing based on the distributions of transverse electrical currents of single-stranded DNA while it translocates through a nanopore. Our estimates, based on the statistics of these distributions, reveal that sequencing of an entire human genome could be done with very high accuracy in a matter of hours without parallelization, that is, orders of magnitude faster than present techniques. The practical implementation of our approach would represent a substantial advancement in our ability to study, predict, and cure diseases from the perspective of the genetic makeup of each individual.

Source: Nano Letters

DOI: 10.1021/nl0601076

Authors: Johan Lagerqvist, Michael Zwolak, Massimiliano Di Ventra

Institutions: California Institute of Technology, University of California San Diego

Language: English

Topic: Nanopore and Nanochannel Transport Studies

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: green

Funders: National Science Foundation, National Institutes of Health, National Human Genome Research Institute

Award: Nanoscale Fluidic Technologies for Rapidly Sequencing Single DNA Molecules